The experienced attacker missed the Nationalelf's last few games due to injury, but is set to make his comeback after regaining peak fitness.
Furthermore, Marcel Schmelzer has received a call-up after being forced to miss the World Cup qualifiers against Ireland and Sweden through injury.
Borussia Dortmund goalkeeper Roman Weidenfeller could make his debut for Germany's senior side as he replaces Robert Zieler in the 24-man squad.
Meanwhile, Bayern Munich midfielder Bastian Schweinsteiger misses out as he is scheduled to undergo surgery on his right ankle.
Germany take on Italy on November 15 in Milan, before travelling to London for the game against England four days later.
|Manuel Neuer||Bayern Munich|
|Roman Weidenfeller||Borussia Dortmund|
|Sami Khedira||Real Madrid|