The 62-year-old coach says la Roja's goalkeeping position is up for grabs between the Real Madrid shot-stopper, Victor Valdes and Pepe Reina
Casillas, who has found his playing time significantly reduced at club level since Diego Lopez became favourite ahead of the 32-year-old, could now find himself in a similar position in the international fold.
And with Spain showing an incredible amount of depth with Pepe Reina and Friday's starter Victor Valdes all ready to deputise in his position, Del Bosque says any of his shot-stoppers could play against Georgia on Tuesday and in the future.
"We'll surely make some changes and one of them could be in goal," he said at a press conference.
"We have three fantastic goalkeepers and any one of them can play. It's not a problem to decide between them. If there's a problem, it's the number of options we have."
Del Bosque also reserved special praise for Iniesta, who returns to his home town Albacete for Tuesday's clash.
He added: "Iniesta's an example on and off the field, a global figure, an excellent example."
Meanwhile, the 62-year-old coach has urged his side to show more following poor performances in recent times and is expecting teams to be more offensive against Spain at Brazil 2014.
"We have had four bad, uncomfortable games, but of those, France and Belarus played well," he continued. "We are an attacking team but the stats show that we don't concede many goals and we defend well.
"There have been teams who have been on the back foot against us but I don't think that will happen at the World Cup, there will be more open games."