The 22-year-old has been rewarded by national boss Vicente del Bosque and could make his debut for the senior side in the upcoming friendlies against Finland and France
The 22-year-old could make his debut for his national side when Spain host Finland in Gijon before travelling to France four days later.
Despite criticism of the Manchester United defence this season, the young goalkeeper has impressed at times this season, particularly against Real Madrid in the Champions League, and appears to have caught the eye of his national team coach.
De Gea was handed his first call-up when he made the preliminary squad for Spain's successful Euro 2012 campaign but missed out on a place in the final squad.
The former Atletico youth product has represented Spain from Under-15 level up to Under-21 with whom he won the European Championship in 2011.
The full squad list is as follows:
Goalkeepers: Victor Valdés, Pepe Reina, David De Gea.
Defenders: Alvaro Arbeloa, Gerard Piqué, Sergio Ramos, Raul Albiol, Jordi Alba, Cesar Azpilicueta, Nacho Monreal.
Midfielders: Xabi Alonso, Sergio Busquets, Xavi, Javi Garcia, Cesc Fabregas, Andres Iniesta, Isco, Santi Cazorla, Jesus Navas, David Silva.
Strikers: Pedro Rodriguez, Juan Mata, Alvaro Negredo, David Villa.