The striker believes much has changed since his country defeated their South American rivals last time around but is still hoping for victory in the rematch on Friday.
However, the Liverpool star - who scored in the penalty shoot-out which decided that match - insists that frailties remain within the Argentina ranks which he hopes his nation will be able to exploit.
"We're not going through a great [period at] present, and Argentina have improved a lot since we faced them," the 25-year-old told ESPN.
"We must use their defensive weaknesses. We realise that we cannot make mistakes at the back because they will not show us mercy. But we have the potential up front to hurt them."
The match is the first of a World Cup 2014 qualifying double-header for Uruguay, who will also travel on Bolivia the following Tuesday.
La Celeste currently lie fourth in their qualifying group, two points behind leaders Argentina.
Suarez added: "It is very important to win both games of this series so we don't fall behind."