The Gunners slipped to defeat against Napoli in the Champions League on Wednesday and were held to a draw by Everton last Sunday as they missed out on the chance to move seven points clear at the top of the table.
But they remain five points clear of Liverpool and Chelsea at the top of the table and can send another statement of their intent by coming away from the Etihad with at least a point.
Aaron Ramsey is expected to return the starting line-up after coming on as a substitute in Naples, while Manuel Pellegrini once more has a choice to make between Joe Hart and Costel Pantilimon in goal.
Chelsea will be keen to keep pace with Arsenal after Oussama Assaidi's injury-time winner gave Stoke City a shock win over Jose Mourinho's side last time out.
The Portuguese admitted after the game that his team were "in trouble", before expressing concern over a Blues defence which has already conceded 17 times this season - two more than during his entire debut term in charge in 2004-05.
They face a Crystal Palace side who appear to have grown in confidence since Tony Pulis' appointment, having won back-to-back games for the first time this season, but still occupy one of the three relegation spots.
The final game of the weekend sees Tottenham host Liverpool at White Hart Lane.
Spurs have also enjoyed an upturn in form following two come-from-behind away wins on the trot, while the visitors have notched nine times in their past two outings and have scored more than twice as many as Sunday's opponents.
Both sides have injury concerns, though, with Jan Vertonghen missing for Spurs and Steven Gerrard ruled out for up to six weeks.
For all of this weekend's fixtures and predictions, not to mention where we see the matches being won and lost, check out the video at the top of the page!