The Colombia striker knows he is in for a tough time against the Brazil defender and dismissed any competition between himself, Zlatan Ibrahimovic and Edinson Cavani
The Colombia star - who joined the club from Atletico Madrid for €60 million over the summer - has four goals to his name this season already.
And while much of the pre-match talk has surrounded the competition between the 27-year-old and PSG strikers Zlatan Ibrahimovic and Edinson Cavani, Falcao knows his biggest battle will be in overcoming les Parisiens' Brazilian centre-back.
"Everyone will defend his club and try to win. If I can contribute to a good result in goals, it will, of course, be much better.
He told reporters: "There will be respect, as there is respect between all players. I admire the top players and try to learn from them. I have no problem with that.
"They certainly have strengths that I would like to have. But I am focusing on facing Thiago Silva, who is one of the best defenders in the world and is a very important part of the Paris."
The former Porto man has helped his side to the top of Ligue 1 with four wins from their first five games, but Monaco boss Claudio Ranieri stated the striker was still not 100% and Falcao admits he is still adjusting to life at his new club.
"I'm still in an adjustment to the Ligue 1 process, the organisation of the team, my team-mates know their game and this requires time," he continued.
"I acknowledge that I can give more. I hope very soon to be on top of my condition. I've changed city, country, home, language, team-mates and had a daughter recently and they are important facts.
"I adapt gradually. I feel very good about this group, composed of young players who are the future of the club. I am very happy to be with Monaco and I'm 100 % dedicated to the club."