The reigning European and world champions struggled in Sunday's 1-0 international friendly win over China, but Negredo has insisted that things will be different in La Roja's first game at this summer's tournament.
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"They kept things tight at the back, and we misplaced a lot of passes. There's no need to worry, though.
"The match against China wasn't good, but things will be different against Italy. What happened here will benefit us and make us stronger."
Spain's encounter with Italy in Gdansk kicks off at 20:45CET. They take on Republic of Ireland four days later in their second match of the group stage, before locking horns with Croatia on June 18.