After breaking a finger during training, the Norwich City shot-stopper will have to stay at home for the tournament, meaning a call-up for Birmingham City's Jack Butland
The Canaries shot-stopper picked up the fracture during Thursday's training session at the Etihad Stadium and will not fly to Poland and the Ukraine next month.
Birmingham City keeper Jack Butland, who has spent the season on loan at League Two outfit Cheltenham Town, will be promoted to the squad after being put on Roy Hodgson's standby list.
Ruddy produced several commanding displays in goal for Norwich as Paul Lambert's side enjoyed a successful first season back in the Premier League since 2005.
The FA has confirmed that Ruddy will fly out to Norway with the squad to watch Saturday's friendly in Oslo, but will return to Norwich once the team flies back to England.
Meanwhile, Butland will join up with the squad next week in preparation for the friendly with Belgium at Wembley on June 2.