The north London outfit head into the match on the back of a string of impressive results - most recently Sunday's 2-1 derby victory over local rivals Arsenal.
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“It’s a big game and an important week for the club, we've had some big games and we want to continue doing well," the Spurs boss told reporters.
"We will treat it as seriously as we have done before. We probably face the biggest team involved in the last 16.
"They are rebuilding their squad. They have invested in young players and are a club in change. But they're involved in three competitions. The Europa League means a lot to them as it does to us.
"Inter are very experienced in Europe, we need to be aware of their strengths & they will need to be aware of ours.
"We don't want to concede, we want to avoid that and take an advantage to Milan. We want to be as good as we have been.
He also revealed his players are relishing the chance to test their skills against the Serie A giants, and confirmed midfielder Mousa Dembele will be fit to feature.
"The match comes at a good time for us. It shows the importance of the competition," he added.
"The players are buzzing to be involved, it's a great match to be involved in.
“Mousa is okay, Ade [Emmanuel Adebayor] is in with a chance too. The rest is the same."