The Cote d'Ivoire striker could have salvaged a draw against Genclerbirligi at the Turk Telekom Arena, but failed to find the net from 12 yards
The Cote d'Ivoire international came off the bench after 65 minutes when the Istanbul giants were already trailing 1-0, and won a spot kick in the closing stages of the game.
However, he failed to find the net from 12 yards as his attempt sailed wide, much to the frustration of the former Chelsea striker, who angrily kicked out at the spot following his miss, and was unable to make amends.
The 34-year-old will be desperate to bounce back in Tuesday's match versus Schalke as the Turkish giants have set their sights on a spot in the quarter-finals after being held to a 1-1 draw in the Istanbul leg.
Schalke filed a protest to Uefa over the eligibility of Drogba after the first match, but saw their complaint turned down by European football's governing body.