La Roja came into the tournament as the title holders – and two-time European champions – but were swept aside by a Holland side inspired by Robin van Persie and Arjen Robben.
Van Persie and Robben each scored twice, capitalizing on mistakes from the experienced Iker Casillas and Gerard Pique.
There will now be a clamour for Del Bosque to shake up his starting XI but the former Real Madrid boss hinted he would stick with the players who have served him so well in recent years ahead of the Group B clashes with Chile and Australia.
He told SporTV: "There is no need for a revolution. We did not win but we will move on and try to win the next game.
"This is a very delicate moment for us. We must all try to resolve this, beat Chile, and move on from there."
It all appeared to be going to script when Xabi Alonso put Spain ahead from the penalty spot after 27 minutes.
David Silva ought to have made it 2-0 but moments later Netherlands equalised through a fine Van Persie header.
The second half was a rout as Robben, Stefan De Vrij, Van Persie and Robben again completed one of the most surprising results in World Cup history.
Del Bosque added: "It's sport, we must accept defeat. They were better in the second half. If Silva makes it 2-0… but they caught us.
"In the second half they had more chances, found lots of space, we were too weak in defence.
"There were errors but we all fought for the result. We got down mentally, it was not about the physical state."