The Bayern Munich duo missed the previous games against Austria and Faroe Islands due to respective ankle problems, but have earned a recall for the games against Republic of Ireland and Sweden after returning to full fitness.
Meanwhile, Bayer Leverkusen striker Stefan Kiessling has once more been overlooked despite a shortage of attackers at Low's disposal.
With Miroslav Klose and Mario Gomez both injured, last season's top goalscorer in the Bundesliga had been tipped for his first call-up since 2010, but Max Kruse of Borussia Monchengladbach is the sole striker to be included in the squad, with Hoffenheim's Kevin Volland also missing out.
Hamburg's Marcell Jansen replaces injured Borussia Dortmund defender Marcel Schmelzer, while Marco Reus is also included after struggling with illness for the games last month, but club team-mate Roman Weidenfeller is again left out.
A win against Republic of Ireland on October 11 would guarantee Low's men their place at next summer's World Cup.
Squad in full:
Goalkeepers: Rene Adler (Hamburg), Manuel Neuer (Bayern Munich), Ron-Robert Zieler (Hannover).
Defenders: Jerome Boateng (Bayern Munich), Benedikt Howedes (Schalke), Mats Hummels (Borussia Dortmund), Marcell Jansen (Hamburg), Philipp Lahm (Bayern Munich), Per Mertesacker (Arsenal)
Midfielders: Lars Bender (Bayer Leverkusen), Sven Bender (Borussia Dortmund), Julian Draxler (Schalke), Mario Gotze (Bayern Munich), Sami Khedira (Real Madrid), Toni Kroos (Bayern Munich), Thomas Muller (Bayern Munich), Mesut Ozil (Arsenal), Marco Reus, Borussia Dortmund), Sidney Sam (Bayer Leverkusen), Andre Schurrle (Chelsea), Bastian Schweinsteiger (Bayern Munich).
Forwards: Max Kruse (Borussia Monchengladbach)