HSV recorded their first victory of the campaign, while Mainz's 100% start came to a crashing end
Hamburg eased the pressure on coach Thorsten Fink with a 4-0 thumping of newly-promoted Eintracht Braunschweig.
Rafael van der Vaart, Jacques Zoua and a Hakan Calhanoglu double gave HSV their first win of the campaign and move the club into 12th spot.
Sami Hyypia's Bayer Leverkusen, meanwhile, suffered their first defeat of the campaign as they were beaten 2-0 by Schalke at the Veltins Arena.
Marco Hoger put the hosts ahead before the break and Jefferson Farfan netted from the penalty spot in the second half.
It came as a welcome boost to a Schalke side who had earned only one point in their first three matches, albeit against tough opposition.
Mainz 100 per cent start to the season also came crashing to an end against Hannover, who thrashed them 4-1 at the HDI-Arena.
Winger Nicolai Muller notched his fifth goal in four Bundesliga matches to put Mainz ahead after 12 minutes before Hannover stormed back with goals from Mame Biram Diouf, Artur Sobiech, Didier Ya Konan and Edgar Prib.
Wolfsburg overcame the absence of the suspended Luis Gustavo to register a 2-0 victory against Hertha Berlin. The hosts struck twice in the final three minutes of the first half, with Ivica Olic breaking the deadlock before Diego converted from the spot.
Elsewhere in Germany, Borussia Monchengladbach were rampant in their 4-1 victory over Werder Bremen.
Juan Arango gave the home side the lead in a closely fought first half and they stepped up the tempo after the interval.
Raffael doubled Monchengladbach's advantage, which was reduced by substitute Havard Nordtveit's own goal, before Max Kruse and Patrick Herrmann wrapped up the points.
Augsburg capitalised on Javier Pinola's 76th-minute dismissal to beat Nuremberg 1-0. Kevin Vogt's strike six minutes from time continued the Bavarian side's good form after they earned their first win of the campaign against Stuggart last week.