Selecao coach Mano Menezes has decided to make one surprising change to the team after they drew 0-0 with Venezuela in a disappointing opening match
The move comes in light of a disappointing 0-0 draw with tournament outsiders Venezuela in their opening match and Menezes has decided to axe one of the team's leading figures as Brazil look to justify their status as one of the tournament favourites.
The Selecao are otherwise unchanged, with Jadson joining a powerful attacking line-up including Pato and Neymar, as Brazil stick to their 4-2-3-1 formation with Ganso operating as the playmaker.
Premier League duo Lucas Leiva and Ramires begin the match as Brazil's holding midfielders to add balance to the team, while Lucio and Thiago Silva are the starting centre-backs.
Barcelona ace Dani Alves gets the nod at right-back, meaning that Maicon will start from the bench, as do Chelsea's David Luiz and Tottenham Hotspur's Sandro.
Paraguay go into the game with a 4-4-2 system and plenty of experience at the back in the shape of goalkeeper Justo Villar, Dario Veron and Zaragoza defender Paolo Da Silva.
Further forward, there is plenty of experience upfront in the shape of Roque Santa Cruz and Lucas Barrios - the Argentine-born striker who won the Bundesliga with Borussia Dortmund last season.
Brazil: Julio Cesar; Dani Alves, Lucio, Thiago Silva, Andre Santos; Lucas Leiva, Ramires; Jadson, Ganso, Neymar; Pato
Subs: Victor, Jefferson, Maicon, David Luiz, Luisao, Adriano, Lucas, Sandro, Elano, Elias, Robinho, Fred
Paraguay: Villar ; Veron, Da Silva, Alcaraz, Torres; Vera, Ortigoza, Riveros, Estigarribia; Santa Cruz, Barrios
Subs: Barreto, Fernandez, Marecos, Caceres, Piris, Santana, Barreto, Victor Caceres, Martinez, Hernan Perez, Zeballos, Haedo Valdez