The match sees Jose Mourinho and his former apprentice, Andre Villas-Boas, lock horns for the first time since going their separate ways back in 2009. Spurs currently boast the best defensive record in European football, but have only beaten the Blues on three occasions at home in the Premier League.
That said, the first of which, came against Jose Mourninho back in 2006 ...
Elsewhere in the Premier League, Manchester United look to build on their midweek Capital One Cup victory over Liverpool with a home tie with West Brom, while league-leaders Arsenal travel to Swansea.
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Last time out, Didi scored six out of ten, correctly backing Manchester City to defeat rivals Manchester United. Impressive, but still not as good as Gus Poyet who continues to lead the way.
So Greg has had his say, and now you can too! Leave your predictions in the comments below and vote on how you think he will fare.