The Premier League club's interest in the defensive midfielder will bring comparisons to the €30m deal that took Yaya Toure to England from the Catalan giants.
However, Manchester City manager Roberto Mancini has often chosen to deploy Toure in a more advanced attacking role and is believed to be keen on strengthening his midfield, despite the recent arrival of the injury-plagued Owen Hargreaves on a free transfer.
An approach for the Barcelona youth product is expected in January, although it is unknown whether Busquets would be tempted to leave the 2010-11 Champions League winners for big-spending City.
Busquets made 46 competitive appearances for Barca last season.
Download the Goal.com Mobile app, and the world of football will be at your fingertips and in your pocket!