City must become the first side in the history of the competition to overcome a two-goal deficit from the home leg if they are to reach the quarter-finals for the first time.
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"Emotionally it's a tough ask, but emotionally you won't beat how we beat QPR and if anything gives you belief in chasing late causes then it should be that," he told reporters.
"Our team is stronger now than it was then. We are here to try to have one of those great nights."
If, as expected, Barcelona score at Camp Nou, City will need three goals to advance to the last eight - a task Kompany believes his free-scoring team-mates are capable of completing.
"Conceding a goal is not as bad as not scoring," he added. "I still think we will have to score three goals across the period in 90 or 120 minutes. We can think we have nothing to lose.
"If we get a lead, the dynamics will change. To say we can't take the lead – no one will put any money on that."
City boast a formidable array of attacking talent with which to threaten Barcelona, and Kompany admits the team's firepower gives him more confidence.
"I will tell you one thing - I'm just really happy they are on my side," he concluded. "We are looking to the future. It might just be [their night]."