The German playmaker missed a penalty he had won in the early stages before being used as an auxiliary defender on the left wing once Wojciech Szczesny had been red-carded, with the former Real Madrid man heavily criticised for a supposed lack of work rate.
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Arsenal began brightly at the Emirates Stadium, drawing Manuel Neuer into a couple of important saves - including his parry from a tame Ozil penalty. From there, Pep Guardiola's side grew into the match and dominated once they had the man advantage.
Although David Alaba missed a penalty for the Germans, goals from Toni Kroos and Thomas Muller secured a commanding lead ahead of the return leg in Munich.
As for Ozil, Wenger said: "I think it affected Mesut. He was still shaking his head five or 10 minutes after that. It had a huge impact on his performance."