The Premier League leaders have won 13 and drawn one of their last 14 matches away from home but face an intimidating task against last season's Champions League runners-up
Premier League leaders Arsenal are unbeaten in their last 14 matches on the road in all competitions, a run that began back in March with a win over Dortmund’s Bundesliga rivals Bayern Munich.
Klopp, whose side clawed their way back into contention to qualify from a competitive group after their 2-1 win at Emirates Stadium a fortnight ago, believes his charges will draw confidence from their own imperious home form.
He said: "I wouldn’t say they are more dangerous away – they are always dangerous home and away – but every game has its own history.
"We have analysed the game against Munich - it was pretty close until the end.
"We actually believe that it is an advantage to play at home and, if we put all our quality on the pitch, we are very hard to play against. We are also very well prepared.
"Even if we had won the last 70 games at home, it wouldn’t make any difference for Wednesday. It would be just history, just statistics, so therefore I wouldn’t say the 14 games [unbeaten] away are an advantage."
Robert Lewandowski, who added to his winner in north London with a hat-trick in last Friday’s 6-1 win over Stuttgart, will provide Dortmund’s major threat but Klopp believes his Polish striker will be in for a tough night up against Arsenal’s in-form central defenders Laurent Koscielny and Per Mertesacker.
"It is going to be a tough game for Robert, especially when you have two central defenders like Mertesacker and Koscielny," Klopp added.
"Actually, he will have to impose his game and therefore we are going to do video analysis and show the players some things. But it is going to be a tough game."