The fixture comes on the back of four wins from six for Emery's men and the 41-year old coach believes that their good form could provide a springboard for Spartachi to claim victory, despite their opposition's intimidating stature.
"The fact that we are playing Barcelona means it will be a difficult game," he admitted to Uefa.com.
"However, we have reason for optimism because we are also a strong team and have won two of our last three games. We will try to take any opportunities that we have and play our own game.
Our goal is to get three points because are desperate to qualify and be playing in Europe in the spring.In recent times we have gone through a bad spell with injuries piling up but we have to deal with this. We know we will be without Artem Dzyuba and Aiden McGeady, which will make things harder."