Chelsea defender John Terry returns to the side as captain after serving the first game of his four-match domestic ban at the weekend, for racially abusing Anton Ferdinand.
Terry will be expected to wear an armband which conveys an anti-racism message as part of a week of activity by European anti-racism body Football Against Racism in Europe.
Eden Hazard drops to the bench for the visitors replaced by Frank Lampard who also started the club's Premier League clash against Spurs from the bench. He completes a five man midfield which also includes the Brazilian pair of Oscar and Ramires.
Shakhtar Donetsk starting XI: Pyatov, Srna, Kucher, Rakitskiy, Rat, Hubschman, Fernandinho, Alex Teixeira, Mkhitaryan, Willian, Luiz Adriano
Subs:Kanibolitskiy, Kryvtsov, Stepanenko, Gai, Douglas Costa, Ilsinho, Eduardo
Chelsea starting XI: Cech, Ivanovic, Luiz, Terry (c), Cole; Mikel, Lampard; Ramires, Oscar, Mata; Torres
Subs: Turnbull, Cahill, Azpilicueta, Bertrand, Romeu, Hazard, Sturridge