Neither Real Madrid nor Barcelona will be at anything even approaching full strength in the next clash between the sides due to a raft of new suspensions to join those sidelined
The 'battle of the Bernabeu' saw Sergio Ramos pick up a suspension after earning a yellow card, while Pepe's straight red will see him sit out the return leg.
Almost certainly set to miss out is Real Madrid coach Jose Mourinho, who was sent to the stands for what he described as some laughter and clapping towards referee Wolfgang Stark in the aftermath of Pepe's dismissal.
On the other side, Barcelona's substitute goalkeeper Jose Manuel Pinto was the first to see red, the veteran receiving his marching orders for his part in a half-time melee.
It leaves the list of missing names for the second-leg clash longer than it already was. Players in italics could potentially return for the match:
|ABSENT FRIENDS | The players (and coach) set to miss Clasico number four
In more positive news for the two sides, Andres Iniesta is likely to make a comeback for Barcelona, while Ricardo Carvalho returns from suspension for Real Madrid.