Pandev last played in the 1-0 loss to Roma at the end of September and had been ruled out with a knee problem.
Meanwhile, Cambiasso picked up a knock on international duty with Argentina and was expected to be out for a longer period of time, but it appears he is fit enough to come on as a substitute if his services are required in the second-half.
Diego Milito and MacDonald Mariga remain sidelined for the European champions.
The Nerazzurri and Spurs are currently tied at the top of Group A with four points and will meet at San Siro this evening and then resume pleasantries in two weeks time again at White Hart Lane.
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