With Benzema and Mesut Ozil coming into the starting line-up, Kaka and Jose Callejon both drop to the bench after starting in the 3-2 Copa del Rey triumph over Malaga on Tuesday.
Elsewhere, Sami Khedira is recalled into the side, coming in for the injured Alvaro Arbeloa with Lassana Diarra reverting to right-back.
Madrid have changed their centre-half partnership for the game with Sergio Ramos returning in place of the suspended Pepe while Raphael Varane comes in for Raul Albiol.
A victory for the home side would open up a six-point lead at the top of the table, with Barcelona not due to play Espanyol until Sunday.
Real Madrid: Casillas, Diarra, Ramos, Varane, Marcelo; Xabi Alonso, Khedira; Ozil, Ronaldo; Higuain, Benzema.
Subs: Adan, Sahin, Kaka, Granero, Altintop, Albiol, Callejon
Granada: Roberto, Nyom, Lopez, Diakhite, Siqueira; Mikel Rico, Yebda; Uche, Martins, Benitez; Ighalo
Subs: Juan, Mainz, Jaime, Geijo, F. Rico, Abel, Cortes
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