The goalkeeper is handed his first outing in the competition this term as Roberto Mancini makes eight changes to his starting line-up, while Antonio Alcaraz returns for the Latics
Elsewhere, Roberto Mancini makes eight changes from the side who narrowly beat West Brom 1-0 in midweek, with the likes of Pablo Zabaleta, Vincent Kompany, Yaya Toure and Sergio Aguero all coming in.
Wigan make two changes from the side who lost 3-2 to Swansea City as Antolin Alcaraz recovers from injury to join Jordi Gomez in the starting line-up, with Gary Caldwell and Paul Scharner making way.
Manchester City starting XI: Hart; Zabaleta, Kompany; Nastasic, Clichy; Yaya Toure, Barry; Silva, Tevez, Nasri; Aguero
Subs: Pantilimon, Garcia, Rodwell, Milner, Dzeko, Kolarov, Lescott
Wigan starting XI: Joel; Boyce, Scharner, Alcaraz, Espinoza; McCarthy, Gomez, McArthur; McManaman, Kone, Maloney
Subs: Al Habsi, Caldwell, Watson, Di Santo, Henriquez, Fyvie, Golobart