Micah Richards misses out for the visitors as Pablo Zabaleta comes in at right-back while Hugo Rodallega lines up in attack for Roberto Martinez's side at the DW Stadium
The Spaniard missed the League Cup semi-final first leg defeat to Liverpool last week although has recovered from an ankle knock and starts at the DW Stadium.
Micah Richards misses out with a reported hamstring injury although Mancini has confirmed he should be back in contention to face Tottenham on the weekend.
There are, meanwhile, eight changes to the Wigan team that lost 2-1 away at Swindon in the FA Cup last week with top scorer Franco Di Santo dropping to the bench.
Wigan starting XI: Al Habsi; Stam, Alcaraz, Caldwell, Figueroa; Crusat, McCarthy, Gomez, McArthur; Moses, Rodallega
Subs: Pollitt, Gohouri, Watson, Di Santo, McManaman, Boyce, Sammon
Manchester City starting XI: Hart; Zabaleta, Savic, Lescott, Clichy; Milner, Barry, Silva, Nasri; Aguero, Dzeko
Subs: Pantilimon, Johnson, Kolarov, Hargreaves, Onuoha, De Jong, Rekik