The Belgian international plays in the unfamiliar full-back role due to the absence of Bacary Sagna and Andre Santos, after the Brazilian damaged his ankle in the midweek Champions League defeat to Olympiakos.
Theo Walcott and Gervinho continue to flank Robin van Persie up front, whilst Aaron Ramsey, Alex Song and Mikel Arteta all start in midfield - the latter facing his former club for the first time since his deadline day switch to the Emirates.
Arsenal starting XI: Szczesny; Djourou, Mertesacker, Koscielny, Vermaelen; Arteta, Song, Ramsey; Walcott, Van Persie, Gervinho.
Subs: Almunia, Rosicky, Arshavin, Frimpong, Chamakh, Benayoun, Miquel.
Everton starting XI: Howard; Hibbert, Heitinga, Jagielka, Baines; Bilyaletdinov, Neville, Fellaini, Coleman; Cahill; Saha.
Subs: Mucha, Stracqualursi, Distin, Gueye, Barkley, Vellios, McAleny.
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