The English striker replaces Dutchman Dirk Kuyt and will play up front with Uruguyan Luis Suarez, while Tottenham remain unchanged and Van der Vaart makes the benchAndy Carroll will start for Liverpool in place of Dirk Kuyt in the Reds' only change from their defeat at Stoke, with the Dutchman dropping to the substitutes' bench.
He joins summer signings Sebastian Coates and Craig Bellamy among the replacements, as Liverpool pick a strong 4-4-2 formation with Carroll joining Luis Suarez up front.
Meanwhile, Tottenham keep the same side that defeated Wolves 2-0 in their last Premier League game, with Ledley King earning a place in the starting XI again.
Dutch midfielder Rafael Van der Vaart has recovered from a hamstring problem, but can only make the bench.
Tottenham (4-4-2): Freidel; Assou-Ekotto, King, Kaboul, Walker; Bale, Parker, Modric, Kranjcar; Defoe, Adebayor.
Subs: Cudicini, Bassong, Corluka, Van der Vaart, Livermore, Pavyluchenko, Giovani
Liverpool (4-4-2): Reina, Agger, Skrtel, Carragher, Enrique; Downing, Lucas, Adam, Henderson; Carroll, Suarez.
Subs: Doni, Coates, Robinson, Maxi, Spearing, Kuyt, Bellamy
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