The English striker replaces Dutchman Dirk Kuyt and will play up front with Uruguyan Luis Suarez, while Tottenham remain unchanged and Van der Vaart makes the bench
He joins summer signings Sebastian Coates and Craig Bellamy among the replacements, as Liverpool pick a strong 4-4-2 formation with Carroll joining Luis Suarez up front.
Meanwhile, Tottenham keep the same side that defeated Wolves 2-0 in their last Premier League game, with Ledley King earning a place in the starting XI again.
Dutch midfielder Rafael Van der Vaart has recovered from a hamstring problem, but can only make the bench.
Tottenham (4-4-2): Freidel; Assou-Ekotto, King, Kaboul, Walker; Bale, Parker, Modric, Kranjcar; Defoe, Adebayor.
Subs: Cudicini, Bassong, Corluka, Van der Vaart, Livermore, Pavyluchenko, Giovani
Liverpool (4-4-2): Reina, Agger, Skrtel, Carragher, Enrique; Downing, Lucas, Adam, Henderson; Carroll, Suarez.
Subs: Doni, Coates, Robinson, Maxi, Spearing, Kuyt, Bellamy
Download the Goal.com Mobile app, and the world of football will be at your fingertips and in your pocket!