Both sides welcome back injury victims at Anfield as Andy Carroll starts for Liverpool while Ledley King makes a long awaited return for Tottenham.
Spurs can move into fifth, above their hosts for the day, if they can win and have King back in their side after overcoming a groin injury that has kept him out since October. He replaced William Gallas at centre-back; the Frenchman is out for the rest of the season with a calf problem.
Harry Redknapp has rung more changes by bringing in Younes Kaboul for Vedran Corluka at right-back, and Steven Pienaar for Wilson Palacios.
Meanwhile, Andy Carroll was not deemed fit enough for Liverpool's 5-2 win at Fulham in midweek but returns to the starting XI alongside Luis Suarez.
Liverpool: Liverpool: Reina; Johnson, Skrtel, Carragher, Flanagan; Maxi, Spearing, Lucas; Kuyt; Carroll, Suarez.. Subs: Gulacsi, Kyrgiakos, Ngog, Cole, Poulsen, Robinson, Shelvey.
Tottenham: Cudicini; Kaboul, King, Dawson, Rose; Lennon, Modric, Sandro, Pienaar; Van der Vaart; Crouch. Subs: Pletikosa, Bassong, Bostock, Livermore, Kranjcar, Pavlyuchenko, Defoe