Scot admits side face a "tough" task at White Hart Lane
The Red Devils are currently on a 20-match unbeaten run in the Premier League and Ferguson admitted all three players should be fit enough to play in the crucial fixture.
"Wayne and Nemanja have both trained well this week and should be fit for Sunday. Edwin is a little bit behind them, but he should train today and I think he'll be okay," Ferguson revealed.
"We've got a good squad available for a really big game. Both teams have had a week's rest so it should be a really fantastic game."
The United boss was full of praise for his opposite number Harry Redknapp and is impressed that the former Portsmouth manager has turned Spurs into title contenders so early into his reign at the club.
"The development of Spurs is an interesting one because I can't remember, and I'm sure I'm right, ever taking United to the Lane with them challenging for the league," he added.
"I might be wrong, but I can't remember them challenging for the league in my time here. That's the change in the fortunes of Tottenham under Harry and they've got some exciting players."
Ferguson admitted his side face a tricky test when they visit the north London club on Sunday but claims it's important for the Red Devils to come through such difficult away fixtures.
"Sunday's game is a big challenge for us. We've got few tough away games in the second half of the season, but you have to get through them," he concluded.