The Spaniard has poured cold water on the suggestion that Friday's game between the Partenopei and the Giallorossi has any bearing on where the Scudetto might end up in May
The Spaniard takes the Partenopei to the Stadio Olimpico to face the Giallorossi who have yet to drop a single point from their seven top-flight matches.
Benitez's men have also started the campaign in impressive form, winning six of their seven games with the only blip being a 1-1 draw with bottom side Sassuolo last month.
Speaking to Il Mattino he said: "There are a lot of matches in Serie A and it is a race based on resistance. The championship is won at the end of the season, not on Friday night."
Benitez moved to the Stadio San Paolo in the close-season, replacing former incumbent Walter Mazzarri, who took the vacant post at Inter - one of Benitez's former clubs.
And the 53-year-old is looking to build a culture of success in Naples.
"We have to remain close to perfection in an effort to win something," he added.
"That is our message - we want to be strong as a team and a club.
"Rather than winning once, I'd prefer to remain at the top for five years."