The Giuseppe Meazza outfit head into the game in seventh place and struggling to compete for the European qualification positions after a dreadful run of one win in nine league games.
Juventus on the other hand are four points off league leaders AC Milan and for this reason, Ranieri believes three points are more imperative for Antonio Conte's men.
"In this situation, the game is more important for Juventus than Inter, so they have more to lose," he told reporters at his pre-match press conference.
"With a defeat, Juve would see Milan break further away at the top of the table. They are also afraid that Inter can be the first team to beat them this season. It's a derby, I know, having been on the other end and realising full well what his game means."
The trainer was talking about his previous spell in charge of the Turin-outfit where he was dismissed from his role two weeks before the end of the season in 2009.
"I took over a side that was coming up from Serie B and lacked many champions. In the last four or five years everything has changed, as they are building a new project, the philosophy and above all, the budget has been totally transformed," he mused.
"Am I disappointed at not continuing in Turin? We all have our karma, our story, and I always reconstructed wherever I went, but never bowed to compromises.
"The reason I left was there were three of us choosing players. At that moment I was excluded from making decisions, then I walked away."
Ranieri concluded his press conference by turning his attention to his own side and believes they may have turned the corner after going through a dismal run of form.
"In recent outings we've seemed less weighed down. Now we are ready to face this Juventus, a side which are doing really well," he added.
"It's not true that we have nothing to lose though. You always want to win a big game and although Juve run the biggest risks, I would've preferred to be in their shoes."