Isco says Real Madrid have a score to settle with Atletico Madrid after last year's lost Copa del Rey final defeat to Diego Simeone's side.
The Santiago Bernabeu side host their city-rivals at the Santiago Bernabeu on Wednesday evening for the first-leg of their semi-final tie, following their 2-1 defeat after extra-time last season.
And the creative midfielder is hopeful los Blancos will emerge victorious this time around and make amends for last season's surprise defeat.
"It will be very difficult but we are very keen to get to the final and settle the unfinished business with Atletico after what happened last year," the 21-year-old was quoted as saying by AS.
"It's going to be a wonderful cup tie, but it's going to be very tight. We hope the semi-final with Atletico goes our way.
"We believe that right now we are in the best form we have shown this season. Now the biggest games of the season are coming up but we are prepared to take them on."
Madrid were beaten 1-0 by Atleti in La Liga earlier this season.