The Dutchman has been plagued by injuries in recent years, but is raring to go again after being given the green light to make his comeback
The Netherlands international underwent surgery on a chronic thigh injury at the start of the season and had since been working on his recovery.
"Ibrahim Afellay is back in action. He has been declared fit and ready to play for the first time since May 12, 2012, when he was in the Barca team that played away to Betis," a statement on the Barca website reads.
"Gerardo Martino has already commented that he is an admirer of Afellay and that he plans to make good use of him now that he is fit again."
The 27-year-old joined the Blaugrana from PSV in January 2011 and won the Champions League and La Liga title in his first six months at the club. He has appeared in 33 official matches for Barca so far, scoring two goals in the process.
Afellay spent the 2012-13 campaign on loan at Schalke, but a series of injuries preventing him from making an impact at the Bundesliga outfit.