The Barcelona skipper will be out of action for three to four weeks when he undergoes an operation on his right knee
The 35-year-old was limited to just 22 games in the 2012-13 campaign due to a string of injuries and will go under the knife on Wednesday.
He is expected to miss between three to four weeks after the procedure.
“Carles Puyol will undergo outpatient surgery to remove a cyst in his right knee,” an official club statement read.
The Camp Nou centre-back last featured for the Blaugrana back in March.