The 44-year-old coach has completed his cancer treatment after spending the last two months in New York and could mark his return to the dugout against the Ligue 1 leaders
The 44-year-old has been out of action ever since he was diagnosed with cancer in his parotid gland for a second time in December and subsequently travelled to New York a month later to begin chemotherapy and radiotherapy treatment following surgery.
However, the Catalan giants have now confirmed that Vilanova will make the trip to Parc des Princes along with the rest of the team, although he is not yet expected to resume his managerial duties.
Vilanova's assistant Jordi Roura, who has filled in during the coach's absence, will hold Barca's press conference prior to the European encounter and should also oversee the side's pursuit of a first-leg advantage.
Barcelona squad for PSG trip: Valdes, Pinto, Alves, Pique, Cesc, Xavi, Villa, Iniesta, Alexis, Messi, Thiago, Mascherano, Bartra, Busquets, Alba, Montoya, Abidal, Song, Tello, Oier, Deulofeu.