The Portuguese centre-back has travelled to his homeland for treatment but is expected to return for the reigning Spanish champions when they take on the Red DevilsReal Madrid defender Pepe has undergone ankle surgery which is likely to keep him out until the upcoming Champions League clash with Manchester United.
The 29-year-old felt discomfort in his right ankle and travelled to Porto for a consultation on Wednesday morning which ended in doctors deciding on medical intervention.
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The first leg of Real's last-16 tie will take place at the Santiago Bernabeu, with the return leg scheduled for March 5 at Old Trafford.
Pepe has played a crucial role for Los Blancos so far this term, making 16 league appearances for Jose Mourinho's side.