The Mexican is confident the culture implemented by Pep Guardiola will live on under the assistant, while he admits the 42-year-old's promotion took the entire team by surprise
The former midfielder oversaw a change in culture at Camp Nou, as he decided to offload more senior members of the squad in Ronaldinho, Deco and Samuel Eto'o at the expense of in-house talents such as Pedro, Isaac Cuenca and Thiago Alcantara.
Dos Santos is one of the players ready to break into the Barcelona first-team, along with defenders Marc Bartra, Martin Montoya and Marc Muniesa, and he expects Vilanova to use Guardiola's work in Catalunya as a platform for his own.
"Tito is the right-hand man of Pep and has always been with him," Dos Santos told EFE. "I think he has the same ideas [as Pep], which may benefit both me and the other young players.
"Vilanova has worked well here in La Masia and, like Guardiola, I think he will only continue to rely heavily on the youth teams.
"He has always supported and encouraged us and he knows a lot about football like Pep. I think he will bring us a lot next year."
The 22-year-old then hailed Guardiola for writing a new chapter in Barca's history, but confessed that he, along with this team-mates, were taken by surprise with the appointment of Vilanova.
"Pep began a new era at the club and did a great job, but it's not a farewell," he continued. "I think it's more of a 'see you later'.
"Nobody expected Tito to come in. Everyone thought he was going out of the club with Pep, but I am delighted for him."