Following their elimination from the Champions League at the hands of Bayern Munich, La Liga is the only competition Los Blancos can hope to win this season.
Jose Mourinho has chosen to make just one change from the team that faced the Bavarians last Wednesday, bringing in Esteban Granero for Sami Khedira in the deep-lying midfield role.
Kaka and Higuain again start from the bench with the coach clearly not worried about fatigue among players such as Karim Benzema, Mesut Ozil and Cristiano Ronaldo.
Sevilla make a number of changes from the team that earned a 1-1 draw with Levanete as Javi Varas replaces Andres Palop in goal while Julien Escude makes way for Juan Cala in defence. Deivid starts in midfield and ahead of him Rakitic and Reyes return at the expense of Luna and Manu.
Real Madrid (4-2-3-1): Casillas; Arbeloa, Pepe, Ramos, Marcelo; Granero, Alonso; Di Maria, Ozil, Ronaldo; Benzema.
Subs: Adan, Albiol, Coentrao, Khedira, Callejon, Kaka, Higuain.
Sevilla (4-2-3-1): Varas; Coke, Cala, Fazio, Navarro; Trochowski, Deivid; Navas, Rakitic, Reyes; Negredo.
Subs: Julian, Campana, Guarente, Luna, De Mul, Baba, Luis Alberto.