The manager has confirmed that Manchester United's record signing will feature against the newly promoted club but that Marcos Rojo will have to wait
The Argentina international moved to Old Trafford in a deal worth €75 million from Real Madrid on Tuesday, becoming United's fourth senior signing this summer.
And Van Gaal has confirmed Di Maria has immediately become part of his plans for Saturday's visit to Turf Moor as he seeks his first Premier League victory.
"I think he is ready to play," the Dutchman told MUTV when asked about the midfielder's chances of featuring.
Fellow Argentine arrival Marcos Rojo, however, is not ready to make his first appearance in a United shirt as he continues to wait on a valid work permit.
"It's only a matter of time," Van Gaal added. "I'm the manager of the biggest club in the world, but I can't change the law!"
Manchester United have started the season in woeful fashion: before being eliminated from the Capital One Cup to a third division side, they had opened their Premier League campaign with a loss and a draw.