The striker has not featured since scoring in a 1-0 win over Arsenal on November 10 due to a groin injury, with David Moyes makes seven changes from the loss to EvertonRobin van Persie has been named in the starting XI for Manchester United's home clash with Newcastle after missing the previous three Premier League games through injury.
Wayne Rooney misses out through suspension after picking up his fifth booking of the season in the 1-0 loss to Everton.
Van Persie - who Goal revealed had returned to first-team training on Friday - is one of seven changes from the midweek defeat, as the likes of Ryan Giggs, Danny Welbeck and Shinji Kagawa - who is struggling with illness - all make way.
Newcastle - whose 3-0 loss at Swansea ended a run of four consecutive wins - make just one change as Alan Pardew bolsters his midfield with Vurnon Anita coming in for striker Shola Ameobi.
Manchester United starting XI: De Gea; Rafael, Evans, Vidic, Evra; Nani, Jones, Cleverley, Januzaj; Hernandez, van Persie.
Subs: Lindegaard, Ferdinand, Anderson, Valencia, Young, Zaha, Welbeck.
Newcastle starting XI: Krul; Debuchy, Williamson, Coloccini, Santon; Cabaye, Tiote, Anita; Sissoko, Remy, Gouffran.
Subs: Elliot, Yanga-Mbiwa, Obertan, Gutierrez, Ben Arfa, Shola Ameobi, Cisse.