Two goals from Barca star Alexis Sanchez ensured the South Americans remain undefeated on English soil, as Roy Hodgson's makeshift side failed to get into the kind of rhythm that saw them beat Montenegro and Poland in October to qualify for the World Cup.
And Wilshere, who was withdrawn on 71 minutes after a subdued performance, insists the last side he played against who pressed and passed so convincingly were the Spanish giants.
"I got a dead calf," he revealed to reporters as the reason for his substitution. "Against South American opposition, you expect little fouls like that and I'll be OK.
"South American teams like to make little fouls and break the game up which is frustrating but we could learn a bit from them sometimes.
"Maybe if we could pick that up from their character, a little foul here and there like they did doesn't hurt.
"Once they do little fouls, it slows play down and you have to stop, build up and it makes it difficult.
"It was a tough game. I think the last time I played against a team like that was Barcelona, the way they keep the ball, the way they play out from the back and when they don’t have the ball they press, they press high and made it difficult for us.
"I think it was very good for us. They were a different style from Ukraine, a different style from a lot of teams we've played in the past and we’ll have to deal with both at the World Cup, especially as there's a few South American teams out there.
"At least we know now what to expect from those sort of teams and we can learn from it."