The England international and the Dutchman have scored 14 goals between them this season, although United sit eight points behind Premier League leaders Arsenal after nine games.
But Moyes believes the pair are still to reach their peak this season and claims that when they do, the partnership will be unrivalled in the Premier League.
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“So I think when those two are firing, then they are the best, I really do. I see that. I think they’re both incredibly talented, both natural goalscorers.
“As footballers they both can probably play in several different positions because of their ability. So I’m looking forward to those two firing.
“And when we hit a real run those two will be something to rival, they really will.”
Moyes also claims Rooney possesses the attributes of a captain but admits he is unlikely to be given the United armband ahead of Nemanja Vidic.
“Wayne has certainly always had the ability to be a captain,” Moyes said.
“He’s got a love of football which is the biggest thing. He loves the game, he loves the ball and kicking around, it’s natural to him.
“If you’ve got that then you’ve got leadership. And in his own way he leads by example in what he tries to do. I think he could be a future skipper here.
“But I’ve not got any reason to change. I’m happy. Vida, Patrice Evra, Rio Ferdinand – all of the really experienced boys are great behind the scenes and captains in their own right.
“Vida wears the armband, but I use them all for their guidance and experience.”