With Vincent Kompany and Micah Richards still out, the Serbian will be fit to partner Joleon Lescott at centre-back against Hull City Tigers after Javi Garcia filled in
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However, Pellegrini has confirmed that the 20-year-old is available for selection against Steve Bruce's side at the Etihad Stadium on Saturday.
"Matija is available to play," the Chilean told the press. "I think Javi Garcia didn'’t do a bad job as he normally plays in midfield but it is Nastasic's natural position, so of course it is better we have him there.
"Nothing is new with Vincent [Kompany's injury]. [At the time] the doctor said it will be four to six weeks. Maybe next week we will see how he improves but less than one month is impossible.
"Micah [Richards] is not available for this game but I hope that next Monday we will start working normally with him."