Last year's Premier League winners trail the Red Devils by 15 points heading into the meeting, with manager Roberto Mancini having conceded his side's title challenge for this season.
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"It would be nice to challenge them on their turf again," Kompany told reporters.
"A derby is a derby. I don't think we could care less about the league in that game.
"It's about who is going to be champions of Manchester. That's all it is.
"I don't expect Manchester United to be less motivated because they have this points gap between us where they are pretty safe.
"It will be like a one-off game. It will be like a cup final. There will be everything in it.
"For the neutrals we have enjoyed a couple of great derbies in the last couple of years. I can only wish the same with a happy ending for Manchester City."