The Argentine replaces his countryman, who picked up a knee injury in training ahead of the trip to Villa Park, where Roberto Mancini's men aim to reduce United's lead to 12 pointsCarlos Tevez starts in place of the injured Sergio Aguero as Manchester City take on Aston Villa in the Premier League.
Roberto Mancini fields an unchanged side barring the change in striker, as the Argentine international is preferred over Edin Dzeko to replace his countryman, who sustained a knee injury during training.
The Blues will be aiming to overcome an inconsistent Villa team and cut the 15-point gap between them and league leaders Manchester United back to 12.
Paul Lambert names the exact same team who lost 2-1 to Arsenal, with Benteke leading the line for the Villans, who are looking for a good result to drag them out of the relegation zone.
Aston Villa starting XI: Guzan; Lowton, Clark, Baker, Bennett; Westwood, Delph; Agbonlahor, N’Zogbia; Weimann, Benteke
Subs: Given, Sylla, Holman, Dawkins, Lichaj, El Ahmadi, Bowery
Manchester City starting XI: Hart; Zabaleta, Kolo Toure, Nastasic, Clichy; Garcia, Milner, Rodwell; Silva, Tevez, Yaya Toure
Subs: Pantilimon, Lescott, Kolarov, Nasri, Sinclair, Barry, Dzeko