The fixture marks the first opportunity for the Netherlands international to play against his former club and the Frenchman has called on the travelling support to give him a good reception.
"I hope it is a respectful reception because he has played for us for eight years, he has done very well for us. You want him to be respected," he told reporters.
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"We campaign against discrimination, it was still the case last week so why should it not be the case this week?
"I don't know what the fans will do, I think he will get the reception I hope for."
The 29-year-old striker enjoyed an eight-year stay at Arsenal before moving to Manchester United for €30.5 million in August. He has scored nine goals in his first 12 games for his new club.