Carlo Ancelotti's assistant believes the striker has the ability to embrace the responsibility that comes with captaincy and has urged him to step up to the mark
The 26-year-old striker has scored 112 times in 235 games for los Blancos since making a €35-million move from Olympique Lyonnais in July 2009 and also has 66 France caps to his name.
However, doubts have remained over his temperament in big games, with Benzema's record for France failing to match his domestic exploits.
Zidane insists he can play an increasingly key role for club and country and start to be seen in the same light as Madrid's traditional leaders.
"I would like Karim to take the initiative at Madrid," the 41-year-old assistant coach said.
"He's the kind of player who doesn't talk much but he has his feet on the ground. He must move up a level to become a leader.
"As in the France team, he can inherit the captain's armband with his club," the 41-year-old continued.
"I hope he meets the challenge next season. Karim can talk to the group, rather than have others do it for him."
France begin their World Cup campaign against Honduras on Sunday, with Benzema set to star in a wide left role to accommodate Olivier Giroud down the middle.