The Blues skipper starts his first Premier League game since the 3-2 defeat to Newcastle in February, while Eden Hazard is named on the bench and Juan Mata misses out completelyChelsea boss Rafael Benitez has rung the changes for the Premier League clash with Southampton, with Ashley Cole, David Luiz, Eden Hazard and Demba Ba all benched while John Terry and Fernando Torres are handed starts.
It's the first time that the Blues skipper has started a league game since February 2, while Juan Mata is left out of the squad completely ahead of Monday's FA Cup quarter-final replay against Manchester United.
Marko Marin is handed a rare start in midfield while Ryan Bertrand is given a chance to impress at left-back and Torres is named up front after being left out of the 2-0 win over West Ham last time out.
For Southampton, manager Mauricio Pochettino is without injured midfielder Adam Lallana while Luke Shaw and Jos Hooiveld are fit enough to start in defence.
Southampton: Boruc; Clyne, Hooiveld, Yoshida, Shaw; Rodriguez, Schneiderlin, Cork, S.Davis, Puncheon; Lambert
Subs: K.Davis, Fonte, Fox, Forren, Ramirez, Ward-Prowse, Guly
Chelsea: Cech; Azpilicueta, Ivanovic, Terry, Bertrand; Mikel, Lampard; Moses, Oscar, Marin; Torres
Subs: Turnbull, Cole, David Luiz, Ramires, Hazard, Benayoun, Ba