David Moyes's under-pressure side will look to make it three wins in a row when they travel to the Britannia Stadium in the quarter-finals of the Capital One Cup
The Premier League champions went four top-flight games without victory over the end of November and beginning of December, including back-to-back 1-0 defeats at Old Trafford to Everton and Newcastle.
United have improved in their last two fixtures, however, beating Shakhtar Donetsk 1-0 in their final Champions League group game before comfortably seeing off Aston Villa 3-0 in the league on Sunday.
And Moyes is now targeting continued improvement, with United looking to make the semi-finals of the competition for the first time since winning the trophy in 2010 in their visit to the Britannia Stadium on Wednesday.
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United have seen off challenges from Liverpool and Norwich City to make it this far and will be confident of claiming the scalp of Mark Hughes's side, with Stoke having never beaten the Red Devils in the Premier League.
Indeed, the Potters' last victory over United in any competition came in a 2-1 League Cup triumph in September 1993 thanks to a double from Mark Stein.
However, at that time, ties in the competition were staged over two legs and United progressed courtesy of a 2-0 success at Old Trafford.
Former Red Devils striker Hughes is looking to orchestrate Stoke's best performance in the competition since their 2-1 triumph over Chelsea in the 1972 final. The club have twice reached the quarter-final stage since then - most recently in the 2008-09 season, when they lost 1-0 to Derby County.
Stoke head into this game on the back of two draws and a win in the top flight, with 0-0 stalemates against Cardiff City and Hull City sandwiching a superb 3-2 triumph over Chelsea.
Centre-back Robert Huth (knee) is ruled out for the hosts, while United will definitely be without Robin van Persie (thigh) and Michael Carrick (Achilles).